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March 2020

This sample is an artificially created blood vessel inside organ-on-chip co-cultured with tumors that is fixed and stained for vascular cell adhesion junctions and key barrier regulatory proteins. Degradation of adhesion junction protein VE-Cadherin (green) is observed in the vessel due to cancer inflammation with a distinct up-regulation of Src kinase (yellow). This vascular dysfunction further provides routes to the blood platelets for extravasation into the tumors that promotes metastasis. Image taken on Olympus FV1000 confocal  at 400 micron X 200 micron field of view and 20X magnification. Image courtesy of Dr. Stanislav Vitha and sample courtesy of Biswajit Saha (Biomedical Engineering).